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doi: 10.1080/13547500410001728390

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However, this approach is not without limitations, including glucocorticoid resistance, the occurrence of numerous adverse effects, suboptimal drug delivery, and other complicating factors that collectively necessitate the pursuit of innovative therapeutic avenues [6]

By using this method, we produced a GPx3 mutant, which showed significant activity in reducing both H 2 O 2 and PLPC-OOH